Cholesterol reduction and total mortality.

Low and lowered cholesterol and total mortality.

he paper by Strandberg et al. (1) in this issue of the Journal onfirms that in relatively young, healthy men from higher ocioeconomic strata, a (naturally) low total cholesterol TC) is associated with increased longevity (2); on average, uch men will have lower levels of low-density lipoprotein LDL) cholesterol. Thus, if you are fortunate to have a low C as a young man, typically a product of a...

Total cholesterol and risk of mortality in the oldest old.

BACKGROUND The impact of total serum cholesterol as a risk factor for cardiovascular disease decreases with age, which casts doubt on the necessity for cholesterol-lowering therapy in the elderly. We assessed the influence of total cholesterol concentrations on specific and all-cause mortality in people aged 85 years and over. METHODS In 724 participants (median age 89 years), total cholester...

Total cholesterol, severity of stroke, and all-cause mortality.

To the Editor: The association of blood cholesterol with the risk of stroke, a very important clinical and public health issue, appears to be in dispute. To fuel the debate, Olsen et al1 reported a study of 513 patients admitted in a Copenhagen, Denmark hospital with acute ischemic stroke. All study data, including measures of total serum cholesterol (TSC) and the severity of stroke, were colle...

Relation of coronary heart disease incidence and total mortality to plasma cholesterol reduction in randomised trials: use of meta-analysis.

Modeling total cholesterol as predictor of mortality: the low-cholesterol paradox.

Elevated total cholesterol is well-established as a risk factor for coronary artery disease and cardiovascular mortality. However, less attention is paid to the association between low cholesterol levels and mortality--the low cholesterol paradox. In this paper, restricted cubic splines (RCS) and complex survey methodology are used to show the low-cholesterol paradox is present in the laborator...